Table 29.1 (continued)

Plant spp. used

Dose (mg/kg), admin.

route

Animal models

Possible mechanism of action

Reference

Silymarin

200 mg/kg, orally

Normotensive male Wistar rats,

APAP-induced hepatotoxicity

Due to anti-inflammatory and antioxidant

properties

Freitag et al. 2015,

Vargas-Mendoza

et al. 2014

Glycyrrhizin

25 and 50 mg/kg, i.p.

Adult male Wistar rats, CCl4-induced

hepatotoxicity

Glycyrrhizin in combination with

silymarin helps in the healing of necro-

inflammatory lesions induced by CCl4

Rasool et al. (2014)

Curcumin

100 mg/kg, orally

Sprague-Dawley rats,

dimethylnitrosamine-induced liver

cirrhosis

Due to anti-inflammatory effect and

suppression of HSC activity which

thereby attenuate fibrosis

Kyung et al. (2018)

Rhein

20, 50 and 100 mg/

kg, orally

Male Wistar rats, methotrexate-

induced hepatotoxicity

Through Nrf2-HO-1 pathway activation to

enhance the liver antioxidant status

Bu et al. (2018)

Geniposide

25, 50 and 100 mg/

kg, orally

400 mg/kg, orally

Male Sprague-Dawley rats, high fat

emulsion-induced non-alcoholic

steatohepatitis

Male Kunming mice, CCl4-induced

hepatotoxicity

Through free radical scavenging activity

Via induction of antioxidant defence

Ma et al. (2011),

Chen et al. (2016)

Resveratrol

100 and 200 mg/kg,

orally

Male C57BL/6J mice, ethanol-

induced liver damage

By suppression of lipid peroxidation and

activation of SOD gene expression

Chen et al. (2016)

556

H. Singh et al.